Although ACC1 is recognized as an oncoprotein in various cancer cells including prostate cancer, glioblastoma, colon cancer, and liver cancer (Brusselmans et al. 2005; Zhan et al. 2008; Jones et al. 2017; Ueda et al. 2019; Ye et al. 2019a, b), there is evidence that ACC1 can act as a tumor suppressor by modulating the energy homeostasis or attenuating protein acetylation in tumor xenograft models (Jeon et al. 2012; Rios Garcia et al. 2017). The gene discussed is ACACA; the disease is liver cancer.