ACC1 knockdown using siRNA inhibits the proliferation of highly lipogenic prostate cancer LNCaP, glioblastoma U87 EGFRvIII cell lines, colon cancer HCT-116, and liver cancer HepG2 cells (Brusselmans et al. 2005; Zhan et al. 2008; Jones et al. 2017; Ye et al. 2019a, b) but does not affect the proliferation of normal cells (Brusselmans et al. 2005). The gene discussed is ACACA; the disease is malignant colon neoplasm.