Since Hsp90 had been found to support the size increase of cardiomyocytes following myocardial infarction (Tamura et al., 2019), we wondered whether it plays any role in the stress-induced cell size increase, and if so, which one of the two cytosolic Hsp90 isoforms, that is Hsp90α or Hsp90β (Maiti and Picard, 2022). The gene discussed is HSP90AB1; the disease is myocardial infarction.