Using these systems, it has been reported that oncogenic forms of Ras, Notch, or Yki synergize with various tumor suppressor mutations or oncogene overexpression, such as Scrib, Src, Mef2, miR-8, BAP, and PP6 protein complexes, to drive tumorigenesis and invasion (Brumby and Richardson, 2003; Pagliarini and Xu, 2003; Pallavi et al., 2012; Ho et al., 2015; Ma et al., 2017; Song et al., 2017; Xie et al., 2017; Sander et al., 2018). The gene discussed is SCRIB; the disease is neoplasm.