PKM and leukemia: In leukemia, IGF2BP3 directly binds to target mRNA and is involved in regulating alternative splicing events.[25] Additionally, IGF2BP3 directly binds to PKM mRNA and regulates its splicing in lung cancer.[24] Consistent with previous research,[23] a portion of IGF2BP3 translocates to the nucleus in the absence of SLC27A5, regulates the alternative splicing of PIP4K2A mRNA by directly binding to it, and is involved in the progression of liver cancer.