As a significant RBP, insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) exhibits infrequent nuclear translocation and is involved in mRNA processing.[23, 24, 25] Additionally, it contributes to cell proliferation and metastasis in various cancers.[26, 27, 28] Our study identified IGF2BP3 as a new potential SLC27A5‐interacting protein in hepatoma cells. This evidence concerns the gene IGF2BP3 and hepatocellular carcinoma.