AKT1 and glioblastoma: A previous study has shown that PIP4K2A binds to P85 and promotes its ubiquitination in glioblastoma cells to inhibit the PI3K/AKT signaling pathway.[36] In our results, we also discovered that the SLC27A5/IGF2BP3 complex was involved in regulating the PI3K/AKT signaling pathway (Figure 4A).