Solute carrier family 27 member 5 (SLC27A5, also known as FATP5), which is exclusively expressed in the liver, is involved in fatty acid transport and bile acid metabolism.[8] SLC27A5 has been demonstrated to function as a novel tumor suppressor in HCC and is positively correlated with HCC prognosis.[9, 10] Further, SLC27A5 deficiency can activate the NRF2/TXNRD1 pathway by increasing lipid peroxidation in HCC.[11] Nevertheless, whether SLC27A5 plays non‐metabolic‐specific functions and regulates HCC progression remains unclear. This evidence concerns the gene TXNRD1 and hepatocellular carcinoma.