Delocalized proteins also included the intermediate filament Krt7 (which is not only delocalized but also increased in both antra and corpora in the presence of atrophic gastritis) and several components of vacuolar ATPases involved in controlling intra- and extracellular pH (58); differential expression of Krt7 and vacuolar ATPases has previously been implicated as potential negative prognostic biomarkers in several cancer types (59, 60). This evidence concerns the gene KRT7 and cancer.