Mathivananet al also found a significant increase in the expression of CD63 and a decrease in the expression of CD9 and CD81 in exosomes present in the saliva of oral cancer patients compared to that of the exosomes in the saliva of healthy individuals.6 Exosomes are recognized by the molecular biomarkers that they express; namely, CD63, CD9, CD81, Alix, TSG101 and hsp70.15 The gene discussed is CD81; the disease is lip and oral cavity carcinoma.