Other than this, active targeting of GBM using nanocarriers can also be achieved by modifying them with either peptides such as iRGD, chlorotoxin, T7 (HAIYPRH- binds transferrin receptor) and F3 (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK- binds nucleolin) or using small molecules such as folic acid or it can also be accomplished by cytokine mediated targeting of GBM using Interleukin-I3 specific to IL-I3Rα2 receptor [[320], [321], [322], [323], [324]]. This evidence concerns the gene NUCLEOLIN and glioblastoma.