The major targets of miR-34a and miR-128 in context to GBM as reported in numerous studies include SIRT1, c-Met, NOTCH1 and NOTCH2, PDGFRα, MSI1, Akt and Wnt for miR-34a; and P70S6K1, SUZ12, Bmi-1-, PDGFRα, EGFR, E2F-3a, WEE1 and MSI1 for miR-128 [[111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]]. This evidence concerns the gene MSI1 and glioblastoma.