According to our results, ACE I/D polymorphism did not demonstrate any clear relationship with COVID-19 risk with the use of diverse genetic models (D vs. I: OR = 1.25, 95% CI = 0.96–1.64; DD vs. II: OR = 1.89, 95% CI = 0.95–3.74; DI vs. II: OR = 1.75, 95% CI = 0.92–3.31; dominant model: OR = 1.88, 95% CI = 0.99–3.53; and recessive model: OR = 1.24, 95% CI = 0.81–1.90). Here, ACE is linked to COVID-19.