The current study focused on new patients not previously identified with a MG as there is ongoing discussion regarding the ideal MG screening test combination: SPE/IFE and SFLC or SPE/IFE and UPE/UIFE.1,27 In a recently published clinical update article, Rajkumar recommended that the initial investigation for a patient suspected of having MM should include SPE, serum IFE and SFLC.1 This is based on a study by Katzmann et al., who identified 428 patients with positive M-protein on urine IFE and determined the diagnostic sensitivity of different screening strategies. This evidence concerns the gene MYOM2 and Miyoshi myopathy.