A limitation of SPE is that it can only identify M-proteins with a concentration greater than 500 mg/L – 2000 mg/L, and patients with lower concentrations of M-protein, such as those with oligosecretory myeloma, may be missed, especially if the M-protein is a free light chain.5,6 Also, for accurate quantification of the M-protein in urine, a 24-h urine collection is preferred over a random specimen. The gene discussed is MYOM2; the disease is plasma cell myeloma.