Only 2 of the 12 up-regulated ISGs (CXCL10 and IFI16) and 2 of the 4 down-regulated (CLDN2 and MX1) were common between HEV-3c and HEV-3f infection, suggesting that the IFN response might differ depending on the HEV subtype involved in infected swine. This evidence concerns the gene CXCL10 and infection.