Figure 1 and Table 1 showcase a significant downregulation of RBMS2 expression in ccRCC patients presenting with severe disease markers, such as advanced age (P = 0.035), increased serum calcium level (P = 0.002), advanced T stage (P < 0.001), distant metastasis (P < 0.001), advanced TNM stage (P < 0.001), and poorer differentiation grade (P < 0.001). The gene discussed is RBMS2; the disease is nonpapillary renal cell carcinoma.