SERPINA12 and obesity due to melanocortin 4 receptor deficiency: It is present in the VAT of Otsuka Long–Evans Tokushima fatty (OLETF) rats, which are animal models that exhibit both central obesity and type 2 diabetes.63 Levels of vaspin have been observed to increase significantly in both circulating blood and adipose tissue in OLETF rats at 30 weeks, which is the time at which when they exhibit the highest levels of obesity and insulin resistance.