At the same time, miR-146a can also regulate the inflammatory damage caused by astrocyte to neurons through the proinflammatory transcription factor NF-κB, thereby improving the clinical symptoms of AD, ALS, and prion diseases, and may be used as an auxiliary treatment of neurodegenerative diseases and as a diagnostic biomarker [77–80]. Here, NFKB1 is linked to amyotrophic lateral sclerosis.