In HD, miR-124 can also protect the nerves from damage by regulating the activation of JAK/STAT3 pathway and activating ribonuclease 4 (RNASE4) to promote angiogenesis, neurogenesis, and neuronal survival, while promoting the reactivity of astrocytes and reducing the number of the Huntington condensates, improving and preventing the occurrence of HD [158–160]. The gene discussed is STAT3; the disease is Huntington disease.