At the same time, miRNAs such as hsa-miR-4488, hsa-miR-196a-5p, and hsa-miR-549a are highly expressed in HD, and miR-196a may regulate neuronal functional status through immune system, adaptive immune system, cytoskeleton remodeling, ABC transporters, etc. It is involved in the transcriptional regulation and translation inhibition of target genes in the development of HD disease, and the change of CAG trinucleotide repeat sequence length is related to the imbalance of miRNAs [60, 37, 61]. The gene discussed is ABCG2; the disease is Huntington disease.