Among the downregulated DEGs, the shared transcription factors include E2F4/DP1, E2F1/DP2, E2F4/DP2, and E2F1/DP1 (Fig. 4B, Additional file 2: Table S3), which have been identified as important contributors to tumor progression in various cancer types [29, 37]. The gene discussed is E2F4; the disease is cancer.