E2F1 and cancer: As for the downregulated DEGs, the top TFs were E2F4/DP1, E2F1/DP2, E2F4/DP2, and E2F1/DP1 (Fig. 4B, Additional file 2: Table S2), which are members of the E2F transcription factor family known to be involved in cell cycle control and cancer progression [29].