Patients with MACE had significantly lower systolic and diastolic blood pressure levels, lower BMI, higher NYHA class, higher NT-proBNP, more dyspnea prevalence, less hypertension and hypercholesterolemia prevalence, larger LA and LV diameter, higher LVEDVI and LVESVI, decreased LVEF and higher prevalence and extent of LGE. This evidence concerns the gene NPPB and familial hypercholesterolemia.