In an MI mouse model induced by ligation of the left anterior descending coronary artery, AIM2, caspase-1, and IL-18 were upregulated, and cardiomyocyte death occurred in peri-infarct or infarct regions of the left ventricle [14], suggesting the high AIM2 inflammasome activities in MI. This evidence concerns the gene IL18 and myocardial infarction.