To further explore the important role of YAP on circGPRC5A/PPP1CA-mediated CRC progression, we demonstrated that the partial reversal of circGPRC5A/PPP1CA-mediated effects on cell proliferation and migration including CCK-8, colony formation, Transwell, and wound healing assays were observed using Verteporfin (YAP inhibitor, 10 ug/mL for 24 h) in HT29 and HCT116 cells (Figure S5A–J). The gene discussed is YAP1; the disease is colorectal carcinoma.