Depletion of NAD+ may disrupt mitochondrial [6] and lysosomal function [7], and compromise the activities of the NAD+ dependent enzymes (e.g. mitochondrial sirtuin (SIRT)3 of the SIRT family) [8], all of which potentially impair host anti-bacterial activity and promote hyper-inflammation and organ failure in sepsis. Here, SIRT3 is linked to Sepsis.