The results of qRT-PCR showed that the relative mRNA expression of cyclin D1 and TERT were significantly downregulated (p < 0.001), while the mRNA expression of p16 (INK4a) was significantly upregulated (p < 0.001) in each tissue of COPD group when compared with control group. The gene discussed is CDKN2A; the disease is chronic obstructive pulmonary disease.