Importantly, using the genetically engineered mouse models (KPC mice) with deletion of SNAI or TWIST, Zheng et al. [36] informed that although suppression of SNAI or TWIST in the primary tumor did not alter the emergence of invasion and blood dissemination of PDAC, it resulted in an increase in gemcitabine sensitivity and overall survival of mice. This evidence concerns the gene TWIST1 and neoplasm.