Bioinformatics results revealed that 25 TFs were aberrantly expressed in PCa, particularly in FOX family (FOXA1, FOXO3, FOXB2, FOXK1, FOXO4, FOXJ2, FOXN3, FOXP3, FOXL2, FOXC2 and FOXS1) and HOX family (HOXA13, HOXB13, HOXC10, HOXC12 and HOXC13). The gene discussed is FOXO4; the disease is posterior cortical atrophy.