These 25 TFs have important regulatory roles in PCa progression, among which FOXA1, FOXK1, GATA2, HOXA13 and FOXC2 have been proven to be oncogenic, while FOXO3, HOXB13, FOXP3 and HNF1B have opposite effects [9–17]. The gene discussed is FOXC2; the disease is posterior cortical atrophy.