We found that 25 TFs were aberrantly expressed in PCa, with FOXA1, FOXB2, FOXL2, FOXP3, FOXS1, HOXB13, HOXC12, HOXC13 and HSF4 being highly expressed in tumor tissues, while ARID5A, FOXJ2, FOXN3, FOXO4, HOXA13, HOXC10, NFIC, NFYB and PGR were lowly expressed (Fig. 1A). This evidence concerns the gene HSF4 and posterior cortical atrophy.