NK cells are plastic, and the function of NKs in melanoma depends on the soluble chemicals (such as TGF-β, TNF-α, PGE2, IL-10, IL-12, etc.)in the melanoma TME and the interactions between cells, whether it be between tumor cells or other cells, can cause infiltrating NK cells to undergo dynamic phenotypic changes. The gene discussed is TGFB1; the disease is neoplasm.