In gastric cancer, transcription factor 4 (TCF4) directly bind to the promoter of Setdb1 gene (binding motif, CAAAG) to enhance the expression of SETDB1, and approximately 90% of patients with gastric cancer (GC) are caused by Helicobacter pylori infection, which promotes SETDB1 expression in a TCF4-dependent manner [39]. Here, SETDB1 is linked to gastric cancer.