KEAP1 and alkaline phosphatase measurement: Silencing p62 reverses the upregulation of Nrf2 and downregulation of Keap1 and Tau proteins induced by AP (P < 0.05, P < 0.01, Fig. 6D-H), indicating that the p62-Keap1-Nrf2 pathway was involved in the anti-cytotoxic process of AP.