CD8 + T-cells (median 36.5%, range [1.9–87.3]) and CD4 + FoxP3- T-cells (38.6% [6.6–74.2]) were more abundant in the tumor microenvironment than CD4 + FoxP3 + T-cells (9.5% [0.1–40.6]), except for MM where no significant differences were observed between CD8 + and CD4 + FoxP3 + T-cells (Fig. 2A). This evidence concerns the gene CD4 and Miyoshi myopathy.