FOXP3 and neoplasm: In the HC_HE compartment, an average of 88.5% of cells in CD8 + clusters belonged to overrepresented clusters within a given tumor (#3, #4, #9, #11, #21 (Supplementary Data 12)), while an average of 81.4% of CD4 + T-cells belonged to CD4 + FOXP3 + (cluster #2) (Fig. 5E).