In consideration of the limited number of studies on relationship between GAB1 gene variants and asthma, the current study aimed to illustrate the association of genetic variation in GAB1 gene with the risk for asthma and the ICS response in asthmatic children, and to assess the modulatory effect of interactions in SNV-SNV and gene-environment between these variants on disease risk. The gene discussed is GAB1; the disease is asthma.