HSPA8 and breast cancer: We also computed the immunoregulation-related pathways scores of BC samples from the TCGA-BRCA dataset as well as examined the associations between the enrichment score of each HCs-mediated TME cell subtype with it, and we found similar significant phenomena that immunoregulation-related pathways scores were significantly elevated in RSF1 + Macro-C1, NAP1L1 + Macro-C2, DEK + Macro-C3, whereas were decreased in NCL + Macro-C7, HSPA8 + Macro-C8, and NoneHistone_Macro-C10, indicating that HCs might play an important role in TME (Fig. 5E).