Notably, the levels of different anti-cancer immune responses, including the release of cancer cell antigens, T cell recruiting, CD8 T cell recruiting, Th1 cell recruiting, NK cell recruiting, and killing of cancer cells, were observed to be significantly elevated in RSF1 + Macro-C1, NAP1L1 + Macro-C2, DEK + Macro-C3, RSF1 + B-C1, HSPA8 + B-C2 and DEK + B-C3, etc. (Fig. 5E). Here, CD8A is linked to cancer.