TLR4 and neurodegenerative disease: The results of GSEA-KEGG showed that gene sets of neurodegenerative diseases and the Toll and Imd signaling pathways were more significantly upregulated in male adults than in female adults (Fig. 3C), whereas Toll-like receptor (TLR) signaling gene sets were enriched in female adults through GSEA-GO analysis (Fig. 3D).