In one study among patients with metastatic prostate cancer (n = 909), Black men were more likely than White men to have actionable mutations overall, specifically in the DNA repair pathway genes (as defined by ERCC5, MRE11, TP53BP1, POLE, RAD21, MSH2, MSH6, BRCA1/2, ATR, and ATM). The gene discussed is POLE; the disease is metastatic prostate carcinoma.