MSH2 and metastatic prostate carcinoma: In one study among patients with metastatic prostate cancer (n = 909), Black men were more likely than White men to have actionable mutations overall, specifically in the DNA repair pathway genes (as defined by ERCC5, MRE11, TP53BP1, POLE, RAD21, MSH2, MSH6, BRCA1/2, ATR, and ATM).