TGFB1 and inborn error of immunity: GSVA analysis showed that pathways enriched in high-risk subgroup included signalling pathways such as TGF-β, WNT, mTOR, Notch and MAPK, while pathways such as DNA replication, proteasome, primary immunodeficiency and antigen processing and presentation were enriched in the low-risk subgroup (Fig. 8A).