As shown in Fig. 4C and D, the SIRS prediction model also performed well in the validation set (AUC = 0.81), showing superiority over the model constructed by individual clinical feature (CRP = 0.525, Fever = 0.423, DBIL = 0.671, Obstruction = 0.644, Bile properties = 0.651, PCT = 0.739, Length = 0.712, Width = 0.537, Volume factor = 0.627). This evidence concerns the gene CRP and systemic inflammatory response syndrome.