Benefits of a genetic diagnosis included the ability to guide familial testing and obtain an early diagnosis of affected family members for 24 families, or to perform surveillance for known complications, such as brain aneurysms in individuals carrying a pathogenic variant in PKD1. Four patients with HFE and PFIC2 will be followed clinically for progression to appropriate stages of disease for cancer screening. The gene discussed is ABCB11; the disease is brain aneurysm.