Collectively, we propose these factors as a possible working model for the regulation of NSCLC distant metastasis (view Fig. S8: The overexpression of miR-660-5p and downregulation of DPYSL2, LIMCH1, PIK3R1, RB1, and TP63 synergistically promotes NSCLC distant metastasis). Here, PIK3R1 is linked to non-small cell lung carcinoma.