ALK and non-small cell lung carcinoma: In addition, KEGG analysis showed that “Cytokine Signaling in immune system,” “RAF/MAP kinase cascade,” “signaling by ALK,” “Signaling by NOTCH,” and “Signaling by WNT” are correlated with NSCLC distant metastasis, demonstrating that these hub genes may be critical mediators of tumor immunity and metastasis [34, 35].