Transcriptomic profiles analyses for these cell lines were conducted, and we identified miR-660-5p and a six-gene signature (ADRB2, DPYSL2, IL7R, LIMCH1, PIK3R1, and SOX2) to be indicative of NSCLC distant metastasis. The gene discussed is ADRB2; the disease is non-small cell lung carcinoma.