On the other hand, at month 2, mice with Abcc6 deletion had lesser kidney fibrosis and displayed a significantly different kidney immune cell distribution then in wt mice (less CD3+ T-cells, more B220+ B-cells and a shift from R1 to R2 macrophages compared to wt mice) suggesting immune modulation and fibrosis prevention. The gene discussed is PTPRC; the disease is fibrosis.