We identified 536 DDX3X coding, canonical splice site and near-exon variants in UKBB or GnomAD, and 239 DDX3X variants in individuals with NDD from ClinVar, DECIPHER, the 100,000 Genomes Project and publications9,26, including variants seen in males and females, with differing clinical interpretations and with differing inheritance. The gene discussed is DDX3X; the disease is Neurodevelopmental delay.