Taken together, the loss of HSP90β isoform in BCR-ABL1 + CML cell lines (K562 and KCL22) leads to an increase in the HSP90α isoform, while loss of HSP90α doesn’t induce changes in HSP90β levels. Here, HSP90AB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.