A consistent upregulation of LCP2 and TOP2A upon HSP90α loss was validated in BCR-ABL1 + CML cell lines (K562 and KLC22) and in BCR-ABL1 + BCP-ALL cell line (SUP-B15) (Supplemental Fig. 3B). Here, TOP2A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.