Furthermore, TKI-resistant BCR-ABL1 + BCP-ALL cells designated as SUPB15r and three (relapsed) PDX cells were included, along with a murine BA/F3 cell line model expressing TKI-resistant BCR-ABL1T315I mutant cells (made resistant to third generation TKI Ponatinib or PN) [4], referred to as BA/F3 BCR-ABL1T315I-PNr cells (Fig. 6B, Supplemental Fig. 6F–H). Here, BCR is linked to acute lymphoblastic leukemia.