Similar to HDACi by Ent treatment, shRNA-mediated depletion of Class I HDACs (HDAC1, 2 and 3) reduced the expression and secretion of LIF (Fig. 4i, j, Supplementary Fig. 6f), Consistent with this, HDAC depletion lowered the capacity of the CAF secretome to activate tumor-intrinsic STAT3 (Fig. 5k) and to support anchor-independent growth in PDAC cells (Fig. 5l). This evidence concerns the gene STAT3 and neoplasm.