ZBTB33 and Familial prostate cancer: The role of GATA2 as mediator of AR signaling in AR-dependent prostate cancer, as well as its role as a potential target for treatment development45 has been previously described, as silencing of the gene is known to affect other relevant genes such as C-MYC and AURKA. Proteins bound to the promoter region include: ZBTB7A, ZBTB33, TCF3, SF1, NR2C2, KLF3, EGR1, E2F1 and CREB1, but most importantly, the EPIN presents AR bound to the enhancer region, which, as we pointed out with MYC EPIN, is the target of several PrCa treatments.