RRM2 and cancer: We identified 3 out of 26 promoter EPINs (TRIM26, MEIS1, POU2F2) with suggestive evidence (p-value < 1e−5) of association between the PrCa SNP with the PENGUIN-linked promoter EPIN, pointing to the cancer promoting mechanistic action of these variants: gene with SNPs in POU2F2 linked to the EPIN promoter of gene PHGDH (SNP with lowest p-value rs113631324 = 3.80e−8); gene with SNPs in TRIM26 and EPIN promoter of gene RRM2 (SNP with lowest p-value rs2517606 = 2.69e−7); gene with SNPs in MEIS1 and EPIN promoter of gene STOM (SNP with lowest p-value rs116172829 = 8.19e−6).