The role of GATA2 as mediator of AR signaling in AR-dependent prostate cancer, as well as its role as a potential target for treatment development45 has been previously described, as silencing of the gene is known to affect other relevant genes such as C-MYC and AURKA. Proteins bound to the promoter region include: ZBTB7A, ZBTB33, TCF3, SF1, NR2C2, KLF3, EGR1, E2F1 and CREB1, but most importantly, the EPIN presents AR bound to the enhancer region, which, as we pointed out with MYC EPIN, is the target of several PrCa treatments. This evidence concerns the gene CREB1 and Familial prostate cancer.