IL11RA and COVID-19: LncRNA RP11-773H22.4 also showed potential for differentiating severe and mild COVID-19 patients; its serum expression was increased in the severe patients compared to mild ones, which could cause downregulated miR-4257 and subsequently upregulated IL-11 receptor subunit alpha (IL-11RA) mRNA thereby promoting inflammation.32 The AUC for lncRNA RP11-773H22.4 in this cohort was 0.78, with a sensitivity of 0.78 and specificity of 0.71.