As we screened, an important lncRNA NEAT1, its elevation can regulate the inflammation of neurons and involve in the susceptibility to COVID-19 infection.135,136 Upregulated NEAT1 was also reported in patients with ischemic stroke, and knockdown of NEAT1 can alleviate the apoptosis and improve neuronal viability.137 This result suggests a possible role of NEAT1 in the pathogenesis of stroke in COVID-19 cases. The gene discussed is NEAT1; the disease is ischemic stroke.