TMPRSS2 and infection: In Vero-TMPRSS2 cells, we found that both BA.2.86 and XBB.1.5 made infection foci which were 5-fold and 4.5-fold smaller in area relative to ancestral SARS-CoV-2 D614G at 20 h post-infection (Fig. 2A rows 1, 3, and 5, quantitation in Fig. 2B).