The mCAs in BL cases affected chromosomal regions with genes that are active in the germinal center dark zone, such as BCL6 or MYC8, and those known to be significantly mutated in BL (PLEKHO1, MCL1, PSMB4, ILF2, HAX1, ATP8B2 and CKS1B), which a mechanistically relevant to general or cellular predisposition to BL47 by affecting MYC overexpression and DNA repair failures48,49. The gene discussed is PLEKHO1; the disease is Burkitt lymphoma.