For example, it has been proposed that tau in other organs such as lung endothelium may interact with and contribute to dysfunction in the central nervous system.2 Salvatore et al. examined pancreatic tissue from control subjects and patients with T2DM, and confirmed the presence of tau in β-cells, where it co-localized with insulin in both control subjects and T2DM patients. The gene discussed is MAPT; the disease is type 2 diabetes mellitus.