Moreover, specifically knocking down tau in the β-islet induced elevated insulin secretion, indicating the importance of pancreatic tau on metabolic traits.1 Of note, pancreatic tau is significantly up-regulated not only in T2DM but also in neurodegenerative diseases like Alzheimer’s disease (AD), dementia with Lewy bodies, Parkinson’s disease, and incidental Lewy body disease.3 This raises intriguing questions. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.