MAPT and type 2 diabetes mellitus: Furthermore, pancreatic tau levels significantly increased in T2DM patients and the T2DM mouse model (db/db mice), highlighting its relevance in the endocrine pancreas in the context of diabetes.1 Indeed, insulin secretion, as indicated by two glucose tolerance tests (intraperitoneal and intravenous), was increased in mid-aged (12-month) tau knockout mice.