TLR4 and Alzheimer disease: In rotenone-induced gut dysbiosis, FMT therapy repairs gut microbiota dysbiosis and suppresses inflammation induced by the LPS-TLR4 signaling pathway both in the gut and brain.350 Besides, the microbiota from AD mice impairs neurogenesis by increasing colonic inflammation, which contributes to memory loss.351 FMT from senescence-resistant mice to AD mice improves spatial learning and memory.352