TGR5 agonists include LCA, DCA, the semi-synthetic BAs, and so on (Table 2).385,386 For example, INT-767 and INT-777 as semi-synthetic BAs activate cAMP, stimulate secretion of GLP-1, and improve hepatic glucose and lipid metabolism in NASH/NAFLD.387. The gene discussed is GCG; the disease is metabolic dysfunction-associated steatotic liver disease.