HAVCR2 and neoplasm: Inhibition of PD-1 improved tumor control by Ptpn22KO CTL, supporting a previous report.7 In contrast, deletion or blockade of TIM-3 was detrimental to Ptpn22KO CTL function, suggesting TIM-3 does not function as a conventional IR in Ptpn22KO CTL and, therefore, is not a good target for reversing exhaustion in Ptpn22KO cells.