However, its limited aqueous solubility hinders its use in medicine.[13] Based on Lawesson's reagent, Moore prepared a novel water‐soluble donor called GYY4137 in 2008,[13] and studies displayed GYY4137 donor has multivalent anti‐thrombosis, anti‐tumor, anti‐shock, and anti‐inflammation functions.[14] The GYY4137 approach displayed neuroprotective outcomes in SCI of diabetic models and altered their sensory deficiencies.[15] Both GYY4137 and NaHS were found to inhibit LPS‐induced NF‐κB receptor activation and release of IL‐1β and tumor necrosis factor alpha (TNF‐α) from the macrophage. The gene discussed is TNF; the disease is neoplasm.