FUS and amyotrophic lateral sclerosis: The RNA-binding protein FUS (fused insarcoma) is a well-studiedprotein that is known to self-assemble into stress granules in cellsand forms inclusions in amyotrophic lateral sclerosis and other neurodegenerativediseases.3 The predominant driving forcefor such self-assembly is the low-complexity (LC) domain of FUS (SYGQ-richsequence), which is intrinsically disordered.6 FUS LC condensation can be triggered by various factors, includingpH, temperature, ionic strength, or molecular crowding,6,10,14,16,23 which makes FUS LC an ideal model for studyingLLPS.