In addition, in line with our finding that overexpression of RAD54L2 in WT cells generates etoposide resistance (Fig. 2D), high expression of RAD54L2 was recently associated with inferior event-free and overall survival of acute myeloid leukaemia (AML) patients in the AML02 cohort (33–35). This evidence concerns the gene RAD54L2 and acute myeloid leukemia.