Nitric oxide-induced changes in the microglia and inflammatory cytokines in the brain mediate the effects of chronic stress on anxiety and depression(45) and inducible NOS and not neuronal NOS is involved in anxiety and depression generation after chronic stress.(7)Increases in NO possibly mediate the formation of anxiety and depressive neurocircuitry in young mice. The gene discussed is NOS2; the disease is depressive symptom measurement.