L-NAME administration possibly reverses this effect, as the nitrergic system participates in anxiety and depression treatment.(7) Exposure to several factors during the perinatal period can have long-lasting effects and contribute to the pathogenesis of various mood and anxiety disorders.(19) Furthermore, we hypothesized that the chronic NOS blockade during early development would affect anxiety- and depression-like behaviors in adult mice. Here, NOS2 is linked to major depressive disorder.