NFKB1 and preeclampsia: As we expected, compared to normal placenta, trophoblasts from placenta of late-onset preeclampsia patients showed over-activated NF-κB (Fig. 4c), while the knockdown of WDR5 rescued phenomenon of over-activated NF-κB observed in trophoblasts from placenta of late-onset preeclampsia patients (Fig. 4c).