Here, molecular differences between FA and PT were screened in both epithelial and stromal components of human biopsies, by sequencing the assessments displayed coordination of some molecular processes between epithelial (EC) and stromal (SC) cell types, including the MED12 and TERT mutations, along with determinant differences acquired by SC that enabled us to fully distinguish PT and FA diseases. The gene discussed is TERT; the disease is Friedreich ataxia.